RapamycinFungusV1, Main, Exploration, bibRecord, 000E20

Recent progress in the study of the Rheb family GTPases.

Identifieur interne : 000E20 ( Main/Exploration ); précédent : 000E19; suivant : 000E21

Recent progress in the study of the Rheb family GTPases.

Auteurs : Jeffrey J. Heard [États-Unis] ; Valerie Fong [États-Unis] ; S Zahra Bathaie [États-Unis] ; Fuyuhiko Tamanoi [États-Unis]

Source :

Cellular signalling [ 1873-3913 ] ; 2014.

RBID : pubmed:24863881

Descripteurs français

KwdFr :
- Animaux (MeSH), Complexe-1 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (métabolisme), Humains (MeSH), Lysosomes (métabolisme), Protéines G monomériques (composition chimique), Protéines G monomériques (génétique), Protéines G monomériques (métabolisme), Structure tertiaire des protéines (MeSH), Système cardiovasculaire (métabolisme), Sérine-thréonine kinases TOR (métabolisme).
MESH :
- composition chimique : Protéines G monomériques.
- génétique : Protéines G monomériques.
- métabolisme : Complexes multiprotéiques, Lysosomes, Protéines G monomériques, Système cardiovasculaire, Sérine-thréonine kinases TOR.
- Animaux, Complexe-1 cible mécanistique de la rapamycine, Humains, Structure tertiaire des protéines.

English descriptors

KwdEn :
- Animals (MeSH), Cardiovascular System (metabolism), Humans (MeSH), Lysosomes (metabolism), Mechanistic Target of Rapamycin Complex 1 (MeSH), Monomeric GTP-Binding Proteins (chemistry), Monomeric GTP-Binding Proteins (genetics), Monomeric GTP-Binding Proteins (metabolism), Multiprotein Complexes (metabolism), Protein Structure, Tertiary (MeSH), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , chemistry : Monomeric GTP-Binding Proteins.
- chemical , genetics : Monomeric GTP-Binding Proteins.
- chemical , metabolism : Monomeric GTP-Binding Proteins, Multiprotein Complexes, TOR Serine-Threonine Kinases.
- chemical : Mechanistic Target of Rapamycin Complex 1.
- metabolism : Cardiovascular System, Lysosomes.
- Animals, Humans, Protein Structure, Tertiary.

Abstract

In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have expanded our understanding of residues that affect Rheb GTP/GDP bound ratios, effector protein interactions, and stimulation of mTORC1 signaling. Analysis of cancer genome databases has revealed that several human carcinomas contain activating mutations of the protein. Rheb's role in activating mTORC1 signaling at the lysosome in response to stimuli has been further elucidated. Rheb has also been suggested to play roles in other cellular pathways including mitophagy and peroxisomal ROS response. A number of studies in mice have demonstrated the importance of Rheb in development, as well as in a variety of functions including cardiac protection and myelination. We conclude with a discussion of future prospects in the study of Rheb family GTPases.

DOI: 10.1016/j.cellsig.2014.05.011
PubMed: 24863881
PubMed Central: PMC4134338

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have expanded our understanding of residues that affect Rheb GTP/GDP bound ratios, effector protein interactions, and stimulation of mTORC1 signaling. Analysis of cancer genome databases has revealed that several human carcinomas contain activating mutations of the protein. Rheb's role in activating mTORC1 signaling at the lysosome in response to stimuli has been further elucidated. Rheb has also been suggested to play roles in other cellular pathways including mitophagy and peroxisomal ROS response. A number of studies in mice have demonstrated the importance of Rheb in development, as well as in a variety of functions including cardiac protection and myelination. We conclude with a discussion of future prospects in the study of Rheb family GTPases.</div>
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Recent progress in the study of the Rheb family GTPases.

Recent progress in the study of the Rheb family GTPases.

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